Overall I'd say I prefer hi-gains on a 6-string (at least vs. scatterwound toasters..pre-scat "hot" toasters are another thing entirely), but that's mostly a function of the kind of music I like to play. And it's definitely not exclusive...my favorite guitar ever is my '64 460, with toasters, and I wouldn't change a thing about it. Of course, this is all in the absence of considering different amps and amp settings, effects pedals, etc.
For 12-strings, I used to be a toaster purist but at one point I owned a '80 360/12 (with original hi-gains) and it sounded phenomenal. So I'm pretty much agnostic now! Also, I haven't had the opportunity to play around with the newer adjustable pole-piece hi-gains, on either a 6- or 12-string, so I'll reserve opinions on these for others who can chime in.
Bottom line is, you need at least four Rickenbackers to cover the basic sting# and pickup permutations, and then from there progress to the hoarding stage to cover the range of models, eras, finishes, etc.
