Rickresource Rickenbacker Forum

I found something here about the possible protective effects of Dogwood on hearing. The experiments were done in vitro. I was looking at a bottle of vitamins, minerals and herbs that I had sitting around for years and Cornus Officinalis was one of the ingredients. NAC also has beneficial effects.

Protective Effect of Ursolic Acid From Cornus Officinalis on the Hydrogen Peroxide-Induced Damage of HEI-OC1 Auditory Cells
The fruits of Cornus officinalis have been used in traditional oriental medicine for treatment of inner ear diseases, such as tinnitus and hearing loss. In the present study, we investigated the protective effect of C. officinalis on hydrogen peroxide-induced cytotoxicity in HEI-OC1 auditory cells. The results from bioassay-guided fractionation of methanol extract of C. officinalis fruits showed that ursolic acid is a major active component. Ursolic acid (0.05-2 microg/ml) had protective effect against the HEI-OC1 cell damage and reduced lipid peroxidation in a dose-dependent manner. In addition, pre-treatment with ursolic acid significantly attenuated the decrease of activities of catalase (CAT) and glutathione peroxidase (GPX), but superoxide dismutase (SOD) activity was not significantly affected by ursolic acid. These results indicate that ursolic acid protects hydrogen peroxide-induced HEI-OC1 cell damage through inhibition of lipid peroxidation and induction of antioxidant enzymes, CAT and GPX, and may be one of the active components responsible for these effects of C. officinalis fruits.

https://pubmed.ncbi.nlm.nih.gov/19655411/

Ursolic acid protects against cisplatin‑induced ototoxicity by inhibiting oxidative stress and TRPV1‑mediated Ca2+‑signaling
https://www.spandidos-publications.com/ ... t=fulltext


N-acetyl-cysteine prevents age-related hearing loss and the progressive loss of inner hair cells in γ-glutamyl transferase 1 deficient mice
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4925825/

Protective effects of N-acetylcysteine on noise-induced hearing loss in guinea pigs
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2808688/

Efficacy of the Antioxidant N-acetylcysteine(NAC) in Protecting Ears Exposed to Loud Music
https://www.audiology.org/sites/default ... _04_04.pdf

A Magic Pill? Compound Could Mediate Noise-Induced Hearing Loss
https://leader.pubs.asha.org/doi/10.104 ... 10082005.5

How about in English?

I've had a bottle of NAC in my cabinet for over a decade now; I had initially purchased it after reading studies about how it had been used for treatment of chronic rhinitis as a product called "mucomyst." I generally pop a few if I feel the sniffles coming on. Back when I was still drinking alcohol: I also noticed that taking some NAC after I've had some booze mitigated some of my "hangover" symptoms.

Composition and method for reducing hangover
https://patents.google.com/patent/US4496548

https://patents.google.com/patent/US20050271754A1

The quest for a hangover cure — could this tablet be the breakthrough for drinkers?
https://www.marketwatch.com/story/the-q ... =bigcharts

taurine
http://news.bbc.co.uk/2/hi/uk_news/magazine/4563760.stm

Does Parkinson’s Begin in the Gut?
https://www.scientificamerican.com/arti ... n-the-gut/

DriftSpace wrote:I've had a bottle of NAC in my cabinet for over a decade now; I had initially purchased it after reading studies about how it had been used for treatment of chronic rhinitis as a product called "mucomyst." I generally pop a few if I feel the sniffles coming on. Back when I was still drinking alcohol: I also noticed that taking some NAC after I've had some booze mitigated some of my "hangover" symptoms.

http://sciliterature.50webs.com/AntisepticLozenges.htm