This insanity does about everything...I can do an entire solo song live with it. I really need to get someone to take some decent video of that.
Pickups on my 370WB or other guitars go to the green Bad Monkey (like a tube screamer but has an additional bass EQ) on the right for overdrive to the Big Muff PI which I use like a treble boost. This then heads to the 4 channel mixer. The piezo from the 370WB goes to the blue Boss compressor sustainer then to the 4 channel mixer. I can also run a vocal mic with an EQ and one additional thing like synths (including a Roland GR30 guitar synth), stylophone or electronic toys to the mixer. Mixer is for setting basic levels and goes to the blue Alesis AirFx in the center which does my effects.
The AirFx makes a softball sized infrared orb so you can control things in an xyz axis. It was made for DJs but I find it perfect for guitar. I use it most for whammy bar like pitch shifts and dive bombs, trem with ring mod, phaser or flanger by moving a foot over it and at times I crouch down and use my hands on the drum sounds for making beats. This all goes to the volume pedal which goes to the Morley A/B box. A goes to the Line 6 and B goes to the Digitech Whammy then to the Line 6 which does delays, reverse and basic looping. The A/B box allows the straight sound or set bass and other pitches with the Whammy either alone or both. I have placed an additional Whammy after the Line 6 on occasion to mess with loops but usually it goes right to the Orange AD30 which is almost always on the clean channel.
I used to run this to a 4x10 cab, Ampeg 4x12 cab or both. I made a simple iso unit for recording out of two 10" car stereo enclosures face to face fitted with a mic. One has a speaker and the other is just the box with either an SM57 or MXL V900 inside. I usually use a 10" marshal cab from a mini stack on the mic box. At times I place a Fender Mustang 1 on top of the mic box when it is just guitar and I want different amp sounds. The mic goes to a PA or to my computer for recording. I'm in the process of cutting some foam and putting the whole deal in a box to avoid any feedback live with the new band. Small room, loud drummer with additional electronic pads & the bass keyboard/electronicist both need the PA.
I can loop with the Line 6 so using overdubs I can make a track & play over it. The volume pedal is mostly used when making loops. This setup is great for songwriting and working out vocal parts & harmonies. The whole idea evolved many years ago in wanting to do anything anytime and I've been using this setup for 5 years now.