As I said in my previous posts, I try to keep my effects rig as simple as possible. I run my 330/12 through a JangleBox JB2 and a J-Gate, and then into my Fender Princeton Chorus amp. And my rig for the 360/12c63 is as simple as it gets: the guitar goes right into the Top Boost channel of my Vox AC15C1. Likewise, for jazz, I run my Guild X-170 archtop directly into my Fender amp, with the reverb turned all the way down. This creates some very rich, fat, mellow tones, particularly with D'Addario Chromes on the guitar.
For great blues and rock sounds, I've custom-designed a number of patches on my GT-100 multi-effects unit, which work nicely with my Stevie Ray Vaughan Signature Model Stratocaster and my PRS SE Tremonti. As I've said, I don't like the onboard wah, so I often insert my CryBaby 535Q into the signal chain. The GT-100 is so versatile that the tonal possibilities are almost limitless.

And it sure beats daisy-chaining 10 or 15 pedals together!